Early exit WP2

REMODEL-HF

REMODEL-HF (Remote Monitoring and Optimization of Heart Failure Therapy)

Clinical validation of a wearable monitoring device, called the Heart Failure Management System (HFMS) to demonstrate improved heart failure management outcomes (hospitalizations, mortality, and biomarker improvement).

Study overview

REMODEL‑HF is a prospective, multi-center, open-label randomized controlled trial evaluating the impact of the Heart Failure Management System (HFMS) on heart failure outcomes. The study compares HFMS-based remote monitoring plus standard of care versus standard of care alone in patients recently hospitalized for acute heart failure.

Objectives

Primary

  • To determine whether HFMS-guided management improves a hierarchical composite outcome at 90 days consisting of:
    • Cardiovascular death
    • Heart failure hospitalization
    • Unplanned emergency visits requiring IV diuretics
    • Change in NT‑proBNP

Secondary

  • Improve GDMT optimization
  • Improve quality of life (KCCQ, EQ‑5D)
  • Delay time to first HF event (death/hospitalization)
  • Assess long-term outcomes at 365 days

Study design

  • Prospective, multi-center, open-label randomized controlled trial
  • 1:1 randomization:
    • Intervention: HFMS + standard of care
    • Control: standard of care alone
  • Device wear: 90 days
  • Follow-up duration: up to 365 days

Participating sites

  • Up to ~45 sites across Europe

Consortium partners

Organisations contributing sites, technology, or expertise to this clinical study.

ZOLL CMS GmbH

Country
Germany
Role
Sponsor
Lead partner